Identifying Research Priorities in Musculoskeletal Trauma Care in Sub-Saharan Africa

A consensus-based approach to identify research priorities for clinical trials and research in musculoskeletal trauma care across sub-Saharan Africa.

Reboot biomedical R&D in the global public interest

Inequitable access to the fruits of research during the COVID-19 pandemic highlights the urgency — and feasibility — of overhauling the R&D system.

My life as a research nurse: Ralueke Ekezie

Ralueke Ekezie is an innovative research nurse in Nigeria, and a long-standing member of Global Health Trials and Global Research Nurses. He has organised many events to support research nurses in Nigeria. Here, he tells us about his role.

Rise in dengue publications

The number of publications about dengue fever has grown strongly since 1960 reflecting strong growth in the number of global cases.  

Study of volunteer blood donors in Martinique provides new information about Zika virus infection

This pioneering study provides a precise follow-up of incident cases and seroprevalence in blood donors, and it also provides important insights into the management of blood donations during ZIKV outbreaks and into the natural history of ZIKV infection in adults. It suggests that the study of blood donors during outbreaks of emerging pathogens has become a key element of epidemiological surveillance.

Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

A study performed by the Institut National de la Santé et de la Recherche Médicale (INSERM) team of Dr Ali Amara (U944, Paris, France) and published in Cell Reports sheds new light on the mechanisms allowing ZIKV to infect cells within the human nervous system. Amara et al. showed that the protein Axl is expressed in a number of brain glial cells and that the entry of ZIKV into these cells requires another protein, Gas6, to act as a bridge between the ZIKV particles and the glial cells.

Zika virus in asymptomatic blood donors in Martinique

This pioneering study suggests that the study of blood donors during outbreaks of emerging pathogens has become a key element of epidemiological surveillance.

Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

A study performed by the Institut National de la Santé et de la Recherche Médicale (INSERM) team of Dr Ali Amara (U944, Paris, France) and published in Cell Reports sheds new light on the mechanisms allowing ZIKV to infect cells within the human nervous system. Amara et al. showed that the protein Axl is expressed in a number of brain glial cells and that the entry of ZIKV into these cells requires another protein, Gas6, to act as a bridge between the ZIKV particles and the glial cells.

Simple reverse genetics systems for Asian and African Zika viruses

By using the bacterium-free ‘Infectious Subgenomic Amplicons’ (ISA) method, this study provides the scientific community with two simple and performing reverse genetics systems for ZIKV.

Clinical trial for experimental Ebola drug publishes results

With video. Results of the Wellcome Trust funded trial of the experimental anti-Ebola drug TKM-130803 have been published in PLoS Medicine. Using a novel approach designed to get rapid indications of a drug’s effectiveness, the trial showed that at the dose given the drug did not improve survival compared to historic controls.

Become a CoLab Member

WHAT IS THE GLOBAL PREGNANCY COLLABORATION (COLAB)? CoLab is a consortium of international investigative groups with data and biological samples from women prior to, during and in some cases, long after an adverse pregnancy outcome. These data and samples are in a membership-wide shared database and available to CoLab members and to investigators sponsored by CoLab members. We currently have members from over 35 centers with more than 300,000 pregnancies and we are growing! We believe the time has come in obstetrical research to pool research and intellectual resources to begin to address and answer questions that could not otherwise be answered by a single investigative group.

How to Get Data and/or Biological Samples

HOW TO COLLABORATE? Applicants with research interests relevant to CoLab (complications of pregnancy) may apply to collaborate with CoLab. Please note that to obtain samples and/or data from CoLab cohorts, you will need a member of CoLab to be your sponsor. We can help assist you in getting a sponsor. All CoLab projects are considered collaborations and you will work directly with CoLab members and cohorts to obtain data and/or biological samples for your project. However, you will work directly with the CoLab office thorough the application process, to give quarterly updates, and to work with a protocol committee regarding your project.

Suppression of the Arboviruses Dengue and Chikungunya Using a Dual-Acting Group-I Intron Coupled with Conditional Expression of the Bax C-Terminal Domain

Research points to a promising single antiviral for the transgenic suppression of multiple arboviruses

Could a protein be key to new dengue drug discoveries?

Scientists belive a protein may be key to new dengue drug discoveries?

TB Partnership looking for Trial Sites - The Critical Path to TB Drug Regimens (CPTR)

  The Critical Path to TB Drug Regimens (CPTR) Initiative is seeking new trial sites for collaboration in planned phase I and II trials.  Also available in French - click on the link and scroll down for French version.

The Draft Statement/Guidelines for Disaster Research

These guidelines were developed following a Working Group on Disaster Research and Ethics (WGDRE) meeting in 2007 with the aim of developing ethical guidelines which would be applicable to post-disaster research, partiuclarly that performed in the developing world. We welcome any feedback from members.